Formulation Development.

Formulation development expertise to take your project from early feasibility and into the clinic.

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Formulation Development

Expertise to support your formulation development project

We have extensive experience in drug formulation development, taking projects from early proof of concept and feasibility, through scale up and onto clinical manufacture for oral, nasal, pulmonary and parenteral dosage forms.

We work closely with clients from the start, defining project aims and understanding the target product profile. Early development includes pre-formulation activities and excipient selection to create the ideal dosage form. Throughout, we focus on formulation suitability, scale-up potential, and commercialisation. Stability studies and extensive analytical techniques ensure product quality.

Once a formulation is ready, we scale the process in our pilot plant, equipped to mirror our GMP facility, ensuring confidence before clinical manufacture.

Our model is built around:

  • One-site delivery for seamless project execution
  • Embedded senior leadership on every project
  • Scalable science that evolves with your programme
  • Flexible, responsive partnerships tailored to biotech needs

When you are ready to begin your CDMO journey, Upperton specialises in:

Inhalation drug products (pulmonary delivery)
Oral solid dosage form tablets and capsules
Oral solid dosage forms (OSD)
Nasal drug delivery systems
Parenteral formulations

Speak to our experts about your formulation development needs

Experts in oral, nasal and pulmonary formulation development.

Our team harnesses advanced techniques and analytical skills to craft diverse dry dosage forms and innovative nasal and pulmonary deliveries.

Start your formulation development project About Us
01

Oral Dosage Forms

Blending
Dry granulation
Milling
Coating
Tablets (IR, MR, SR, Minitabs)
Capsules (API, powder blend, lipid)
Small molecules, biologics, and NCEs
Batch sizes from grams to 250 kg
02

Nasal & Pulmonary
Dosage Forms

Nasal Powder and liquid dosage forms
Pulmonary Powder dosage forms
Spray drying intermediates
Micronisation
Lipid-based formulations
Capsule filling
Device filling
Blister packaging

Formulation Development with Pharmaceutical Spray Drying

Overcoming poor solubility and bioavailability formulation challenges

We’re specialists in the use of pharmaceutical spray drying to improve the solubility and bioavailability of your formulation, helping to enhance the dissolution rate and stability.

01

Spray Drying Expertise

Upperton has over 25 years of expertise in spray drying, using specialist spray drying technology that can scale from R&D through to commercial.

02

Bioavailability Enhancement

Spray drying is an excellent technology that can support with bioavailability enhancement. Our spray drying technology can be used on a range of molecules.

03

Micronisation

Micronisation reduces the average diameter of solid material particles. By drastically increasing the surface-area-to-volume ratio, this technique significantly improves solubility and bioavailability.

Upperton has extensive experience in drug formulation development, with specialist expertise in challenging projects, including those with poor solubility, permeability and bioavailability.”

Dr Richard Johnson

Why Upperton

At Upperton, we specialise in the formulation and development of complex molecules, supporting a wide range of advanced drug delivery systems.

Our expertise spans:

By combining scientific excellence with practical development expertise, we help overcome the challenges of complex drug products and accelerate their path to clinic and market.

partnership

Why Partner with Upperton

We provide fully integrated services across every stage of drug product development:

Microscope and analysis equipment at the Upperton facility

One Site

Integrated, end-to-end capabilities delivered under one roof.

Upperton scientist examining a formulation flask

One Team

The same team from your early-stage development through to preparation for commercial launch.

Test tubes used in complex molecule formulation development

Complex Molecule Expertise:

Proven track record in solving formulation and delivery challenges.

Upperton senior leadership overseeing laboratory work

Executive Leadership on Every Project:

Direct access to experienced senior leadership for strategic oversight and decision-making.

Let's work together

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Formulation Development FAQs

Yes, we offer end-to-end formulation development across a range of dosage forms, including oral solids and liquids, nasal liquids and powders, pulmonary liquids and powders, in addition to sterile dosage forms

Upperton specialises in working with particularly challenging APIs, including those with low solubility, poor permeability, or chemical instability.

We prioritise stability and bioavailability from the earliest stages of formulation development. We conduct comprehensive pre-formulation studies to understand the physicochemical properties of the API. Stability is assessed through ICH-compliant stability studies under various conditions to ensure the formulation remains effective and safe throughout its shelf life.

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We provide fully integrated services across every stage of drug product development.

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