Manufacturing Clinical Supplies: The Early Phase Clinical Manufacture Timeline
Early Phase Timeline Formulation Development Excipient Compatibility Clinical Manufacture FAQs An Overview of Early Phase Clinical Manufacture Clinical trials are a critical step in pharmaceutical development, ensuring the safety and efficacy of new treatments before they reach patients. They involve a series of rigorously designed phases with specific objectives and regulatory requirements. Small pharma companies […]
Manufacturing Clinical Supplies: The Role of Placebos and the Challenges they Present
Manufacturing a suitable placebo dosage form presents many unique challenges over and above those required for the active product.
A Tablet Development Journey at Upperton
With the continued expansion of our tablet formulation development services, Upperton currently have a number of tablet dosage form development projects completed or in progress. Theses tablet / solid dosage form projects have encompassed a wide range of development activities from Active Pharmaceutical Ingredient (API) characterisation and feasibility studies through the application of enabling technologies, […]
Upperton Invest £500K in their Tablet Formulation and Manufacturing Capabilities
29th April 2020 – Press Release Upperton Pharma Solutions, a UK-based contract development and manufacturing organisation (CDMO) have invested £500K in significantly expanding their tablet manufacturing capabilities with the addition of tablet processing equipment for wet granulation, roller compaction, tablet compression, hardness testing, dedusting, weight sorting and tablet coating throughout 2019 and 2020. This investment […]
Stages of Tablet Development: Compression Equipment Overview
Stages of Tablet Compression Equipment Used During Formulation and Process Development Tablets are one of the most popular dosage forms used in the pharmaceutical, nutraceutical and veterinary industries due to their ease of handling and administration, stability, convenient packing options and well-established cost-effective manufacturing processes which produce consistent quality products. Developing a tablet formulation from […]
Formulating Spray Dried Dispersions into Tablets
What Are ASDs? How Are ASDs Produced? Advantages of Spray Drying Challenges in Developing SDDs into Tablets FAQs Loading the Elevenlabs Text to Speech AudioNative Player… Talk to our experts Virtual Facility Tour In this article, Upperton interviewed Dr Ian Lafferty, our Chief Technical Officer on the topic of developing spray dried dispersions (SDDs) into […]
Applications and Techniques of Pharmaceutical Granulation
What is Granulation? Wet Granulation Wet Granulation Options Dry Granulation Dry Granulation Options Loading the Elevenlabs Text to Speech AudioNative Player… Talk to our experts Virtual Facility Tour What is Granulation? Granulation has been widely used in the pharmaceutical industry since the 1950s. Whilst the science remains largely identical to that developed over 70 years […]
Oral Solid Dosage Forms Containing Amorphous Spray Dried Dispersions: Choices for First in Human Studies
The number of amorphous solid dispersions entering first in human (FIH) studies continues to increase, due to the growing number of novel APIs with a poor solubility profile, and associated bioavailability challenges. Spray drying is a useful technology for creating a form of amorphous solid dispersions called spray dried dispersions (SDDs). Spray drying a poorly […]
Selecting a Spray Dryer for Development Studies and Clinical Manufacture
Loading the Elevenlabs Text to Speech AudioNative Player… Talk to our experts Virtual Facility Tour When customers initiate discussions with Upperton, one of the first questions we are asked is “which spray dryer(s) do you have and how much material can they produce?” Whilst these are very pertinent questions, the answer is not a simple […]
Upperton continues to invest in key equipment to support expansion of its solid dosage form capabilities and CDMO Services
29th October 2019 – Press Release Upperton Pharma Solutions, a UK-based contract development and manufacturing organisation (CDMO) has significantly increased its solid dosage form capabilities following a strategic investment in a new state-of the-art tablet coater. This investment will enhance the company’s development and manufacturing capabilities whilst strengthening their ability to support clients’ research, development […]