Nasal Inhalation Delivery – An Introduction Guide
An introduction to nasal delivery The delivery of APIs via nasal inhalation is of growing interest to companies looking to exploit the benefits of this delivery route. Delivery targets are typically broken down into three categories Local delivery to the nasal membranes (e.g. for vaccines, antivirals, prophylactics) Systemic delivery by absorption into the bloodstream (e.g. […]
Nasally Delivered Dry Powder Dosage Forms: Particle Size Analysis
Introduction to Nasal Delivery The delivery of APIs via nasal inhalation is of growing interest to companies looking to exploit the benefits of this delivery route. Delivery targets are typically broken down into three categories Local delivery to the nasal membranes (e.g. for vaccines, antivirals, prophylactics) Systemic delivery by absorption into the bloodstream (e.g. for […]
Upperton’s new Nottingham facility
18th January 2023 Upperton Pharma Solutions, a leading UK contract development and manufacturing organisation (CDMO), is delighted to announce that it has begun construction work for its new Development and GMP Manufacturing headquarters in Nottingham, UK. Working in close collaboration with its principal Design and Build contractor, T-SQUARED the team officially broke ground on the […]
Build of New Development and Manufacturing Facility
29th November 2022 – Press Release & Newsletter Upperton Pharma Solutions Appoints T-SQUARED for Design and Build of New Development and Manufacturing Facility Upperton Pharma Solutions, a leading UK contract development and manufacturing organisation (CDMO), is delighted to announce that it has appointed T-SQUARED, UK based company, as the principal Design and Build contractor for […]
Upperton Launches ASAPprime® Shelf-Life Stability Testing
November 16th 2022 : Newsletter Upperton has made a significant investment in ASAPprime® software and hardware to enable the company to offer its clients state of the art stability testing. This exciting new platform can be used to generate robust, accelerated chemical stability data and is now being applied at all stages of the product […]
In Vitro Testing of Dry Powder Nasal Delivery Devices
Successful nasal drug delivery of dry powder formulations requires a delivered dose that can penetrate beyond the nasal entrance region and deposit in the peripheral nasal cavity, whilst avoiding deeper penetration to the airways of the lungs. This delivery, or deposition pattern, is determined by the aerodynamic particle size of the powder exiting the device, […]
Characterising the Physical Properties of Spray Dried Powders
The Benefits of Powder Characterisation When developing products containing spray dried powders it is vital that the physical properties of the powders produced are determined. The physical properties of spray dried powders provides important information that can assist during the pre-formulation screening and early process development phases since these properties will have a direct impact […]
Growing Interest in Nasal Drug Delivery
Nasal drug delivery route for small molecules and biologics. Recent trends have seen growing interest in exploiting nasal drug delivery as a means of delivering a wide range of drugs including small molecules and larger biologics for a wide range of indications. The nasal cavity is already a well-established delivery route capable of achieving rapid […]
Analytical Techniques for Biotherapeutics
Analysing Biotherapeutic Formulations There is growing interest in the use of spray drying to create biotherapeutic dry powder formulations. Spray drying is becoming increasingly viewed as a more cost-effective method for enhancing the stability of thermo-sensitive molecules (such as proteins, peptides, monoclonal antibodies and vaccines). A key aspect in the successful development of dry powder formulations […]