Nasally Delivered Dry Powder Dosage Forms: Particle Size Analysis
Introduction to Nasal Delivery The delivery of APIs via nasal inhalation is of growing interest to companies looking to exploit the benefits of this delivery route. Delivery targets are typically broken down into three categories Local delivery to the nasal membranes (e.g. for vaccines, antivirals, prophylactics) Systemic delivery by absorption into the bloodstream (e.g. for […]
Upperton Launches ASAPprime® Shelf-Life Stability Testing
November 16th 2022 : Newsletter Upperton has made a significant investment in ASAPprime® software and hardware to enable the company to offer its clients state of the art stability testing. This exciting new platform can be used to generate robust, accelerated chemical stability data and is now being applied at all stages of the product […]
In Vitro Testing of Dry Powder Nasal Delivery Devices
Successful nasal drug delivery of dry powder formulations requires a delivered dose that can penetrate beyond the nasal entrance region and deposit in the peripheral nasal cavity, whilst avoiding deeper penetration to the airways of the lungs. This delivery, or deposition pattern, is determined by the aerodynamic particle size of the powder exiting the device, […]
Characterising the Physical Properties of Spray Dried Powders
The Benefits of Powder Characterisation When developing products containing spray dried powders it is vital that the physical properties of the powders produced are determined. The physical properties of spray dried powders provides important information that can assist during the pre-formulation screening and early process development phases since these properties will have a direct impact […]
Growing Interest in Nasal Drug Delivery
Nasal drug delivery route for small molecules and biologics. Recent trends have seen growing interest in exploiting nasal drug delivery as a means of delivering a wide range of drugs including small molecules and larger biologics for a wide range of indications. The nasal cavity is already a well-established delivery route capable of achieving rapid […]
Upperton Adds New Nasal and Oral Delivery Technologies
January 27th 2022 : Newsletter Upperton is pleased to announce that it has bolstered its nasal and oral delivery capabilities with the addition of a number of new analytical and formulation technologies. Nasal Delivery News – Upperton enhances its analytical capabilities by acquiring next generation nasal particle impaction technology Upperton has acquired the Copley Alberta Idealised […]
Formulation Options in Nasal Drug Delivery
Liquid Delivery Dry Powder Delivery Dry Powder vs Liquid Devices Delivery Considerations FAQs Loading the Elevenlabs Text to Speech AudioNative Player… Talk to our experts Virtual Facility Tour Nasal delivery options The anatomy and physiology of the nasal cavity creates a number of unique opportunities for the successful delivery of drugs and vaccines. This can be […]
Nasal Delivery of Therapeutics and Vaccines
Overview of Nasal Delivery Nasal Physiology for Drug Delivery Nasal Delivery Advantages FAQs Nasal Delivery Overview The anatomy and physiology of the nasal cavity creates a number of unique opportunities for the successful delivery of drugs and vaccines. This can be locally, systemically or directly to the central nervous system. This utility has resulted in […]
Manufacturing Clinical Supplies: The Early Phase Clinical Manufacture Timeline
Early Phase Timeline Formulation Development Excipient Compatibility Clinical Manufacture FAQs An Overview of Early Phase Clinical Manufacture Clinical trials are a critical step in pharmaceutical development, ensuring the safety and efficacy of new treatments before they reach patients. They involve a series of rigorously designed phases with specific objectives and regulatory requirements. Small pharma companies […]
Manufacturing Clinical Supplies: Planning a First-in-Human Study
What are Clinical Trials? What is a First in Human Study? Proof of Concept FIH Studies Commercial Robust Method FAQs What are Clinical Trials? Clinical trials are one of the most important components of any drug development project, requiring careful planning and extensive funding. Clinical trials are conducted to improve the efficacy and quality of […]