Stages of Tablet Development: Compression Equipment Overview
Stages of Tablet Compression Equipment Used During Formulation and Process Development Tablets are one of the most popular dosage forms used in the pharmaceutical, nutraceutical and veterinary industries due to their ease of handling and administration, stability, convenient packing options and well-established cost-effective manufacturing processes which produce consistent quality products. Developing a tablet formulation from […]
Formulating Spray Dried Dispersions into Tablets
What Are ASDs? How Are ASDs Produced? Advantages of Spray Drying Challenges in Developing SDDs into Tablets FAQs Loading the Elevenlabs Text to Speech AudioNative Player… Talk to our experts Virtual Facility Tour In this article, Upperton interviewed Dr Ian Lafferty, our Chief Technical Officer on the topic of developing spray dried dispersions (SDDs) into […]
Applications and Techniques of Pharmaceutical Granulation
What is Granulation? Wet Granulation Wet Granulation Options Dry Granulation Dry Granulation Options Loading the Elevenlabs Text to Speech AudioNative Player… Talk to our experts Virtual Facility Tour What is Granulation? Granulation has been widely used in the pharmaceutical industry since the 1950s. Whilst the science remains largely identical to that developed over 70 years […]
Tablet Formulation: A General Overview
Tablet Formulation Strategies Solid Dosage Forms Tablet Manufacture Process Tablet Press FAQs Loading the Elevenlabs Text to Speech AudioNative Player… Talk to our experts Virtual Facility Tour Tablets continue to be one of the most popular pharmaceutical dosage forms, as with the right tablet formulation you can achieve: ease of handling and administration for patients, […]
Tablets: A General Overview
Listen to the article Loading the Elevenlabs Text to Speech AudioNative Player… What are Oral Solid Tablets? Examples of Tablets Considerations for Tablet Design FAQs Tablet dosage forms are one of the most popular dosage forms used in the pharmaceutical industry due to their ease of handling and administration for patients, stability, convenient packing options […]
Oral Solid Dosage Forms Containing Amorphous Spray Dried Dispersions: Choices for First in Human Studies
The number of amorphous solid dispersions entering first in human (FIH) studies continues to increase, due to the growing number of novel APIs with a poor solubility profile, and associated bioavailability challenges. Spray drying is a useful technology for creating a form of amorphous solid dispersions called spray dried dispersions (SDDs). Spray drying a poorly […]
Assessing Bioavailability Enabling Technologies using Upperton Pharma Solutions Screening Platform – UpperSolv™+
Currently approximately 9 out of 10 new drugs entering clinical trials will fail before reaching approval. Many of these drugs will fail due to problems with ADME (absorption, distribution, metabolism and excretion) rather than lack of efficacy. One of the more common issues associated with ADME is the need for increasing bioavailability. Therefore, it is […]
Upperton is Launching an Enabling Technology Screening Protocol – UpperSolv™
10th December 2019 – Press Release Upperton Pharma Solutions, a UK-based contract development and manufacturing organisation (CDMO) are launching an enabling technology screening protocol which aims to support companies with the rapid development of both standard and complex drug products. The new enabling technology screening protocol, integrates the company’s existing formulation capabilities with a biopharmaceutical […]
Using Spray Drying to Develop Inhaled Dosage Forms
Pulmonary delivery is showing increased popularity as a viable dosage form for treating local airway diseases and offers additional potential for systemic drug delivery. Within this space there are a number of delivery approaches that can be undertaken. These include dry powder inhaled formulations (DPI) and pressurised metered Dose Inhalers (pMDIs). Each of these delivery […]
Selecting a Spray Dryer for Development Studies and Clinical Manufacture
Loading the Elevenlabs Text to Speech AudioNative Player… Talk to our experts Virtual Facility Tour When customers initiate discussions with Upperton, one of the first questions we are asked is “which spray dryer(s) do you have and how much material can they produce?” Whilst these are very pertinent questions, the answer is not a simple […]