Trent Gateway Facility.

One site in Nottingham, UK - built for the development and manufacture of oral, nasal, inhaled, and injectable drug products.

GMP PROCESSING SUITES

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Years of formulation expertise across oral, nasal, pulmonary and parenteral dosage forms
GMP PROCESSING SUITES.

HIGH POTENCY HANDLING

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Average feasibility programmes fixed-scope entry point with a defined deliverable in 8 weeks.

sterile manufacturing

Annex 1

MHRA Approved sterile manufacturing facility, designed against the revised Annex -1 guidelines.

FACILITY SIZE

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R&D, GMP, QC and more all on one 60,000 sq.ft 60,000 sq ft facility in Nottingham, UK

One team, one site .
Helping take your molecule further.

State-of-the-art drug product development and manufacturing facility in Nottingham, UK.

Our state-of-the-art Nottingham facility houses 10 GMP manufacturing suites, quality control laboratories and dedicated analytical and formulation development laboratories with pilot plant facilities.

Trent Gateway has been specifically designed to cater to a wide range of development and manufacturing projects, offering processing of non-sterile dosage forms including solids, liquids, semi-solids, nasal and inhaled products, alongside sterile liquid and dry powder drug products.

Whether you’re in the early stages of formulation development, in need of clinical trial supplies from Phase 1 to Phase 3 or seeking niche-scale commercial manufacturing, Trent Gateway is fully equipped to fulfill your requirements with precision and excellence.

01 — Development and Manufacturing

End-to-end CDMO for Small & Mid-size Biotech

Upperton combines advanced formulation expertise, integrated development capabilities, and single-site execution to ensure speed, efficiency, and control at every stage of your drug product journey.

With 25+ years of expertise in dry powder formulations and complex dosage forms, we take full ownership of your molecule’s lifecycle from early-stage development to clinical supply and beyond.

Research & Development laboratories

  • One-site delivery for seamless project execution
  • Embedded senior leadership on every project
  • Scalable science that evolves with your programme
  • Flexible, responsive partnerships tailored to biotech needs

Research & Development laboratories

  • One-site delivery for seamless project execution
  • Embedded senior leadership on every project
  • Scalable science that evolves with your programme
  • Flexible, responsive partnerships tailored to biotech needs

02 — Capabilities

Science to Move Your
Molecule Forward

We provide fully integrated services across every stage of drug product development:

01

Formulation Development

Optimising stability, bioavailability, and delivery for complex molecules.

02

Phase I–II Clinical Supply

Agile manufacturing to support early-stage clinical trials.

03

Process Scale-Up for Phase III & Commercialisation

Efficient transition from bench to large-scale production.

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Analytical Development & Validation

Robust testing methods to ensure product quality and compliance.

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Analytical Development & Validation

Robust testing methods to ensure product quality and compliance.

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UK Pharma Awards:

Contract Services Company of the Year

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Medilink Midlands:

Innovation of the Year

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Medilink Midlands:

Outstanding Achievement Award

05 — partnership

Why Partner with Upperton

Equipment

Material Sciences
+ Sympactec Laser Particle Analysis
+ Rikagu Miniflex 600-D XRPD
+ TA Dynamic Vapour Sorption Analyser (DVS)
+ TA Thermogravimetric Analyzer (TGA)
+ TA Thermal Analysis Q20 DSC+ Scanning Electron Microscope (outsourced)

Spray Drying
+ ProCepT 4M8-TriX Spray Dryer (aqueous)
+ GEA Niro SD Micro Spray Dryer (aqueous or solvent)
+ Buchi B-290 Mini Spray Dryer (aqueous or solvent)
+ GEA Niro Mobile Minor® (aqueous)

Analytical / Performance Testing
+ HPLC Agilent Series
+ Thermo Trace Gas Chromatography
+ Brookfield DV-III
+ Rheometer
+ Malvern Spraytec Laser Diffraction
+ Copley NGI (Next Generation Impactor)
+ Alberta Idealized Nasal Inlet (AINI)
+ Copley Tablet Disintegration/Hardness Tester
+ Sotax AT7 Dissolution Tester
+ Sotax Dissolution Testing USP I / USP II

Manufacturing
+ Edwards Super Modulyo Freeze Dryer
+ Quantos Precision Powder Filler
+ Atritor M3 Jet Mill
+ Freund-Vector TFC Roller Compactor & Mill
+ Natoli Single Station Tablet Press
+ Caleva Tablet and Pellet Mini Coater Dryer

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Book a guided virtual tour.

Step inside our Trent Gateway facility with one of our subject matter experts, through our guided virtual tour. From the comfort of your laptop, explore our research laboratories, our GMP manufacturing suites, and see how take your molecule from early feasibility through to commerical on one site.

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